Fast, reliable, real-time detection – measure redox-reactive species
Click here to view the current Data Sheet.
Real-time detection and measurement of a variety of redox-reactive species is fast and easy using the electrochemical (amperometric) detection principle employed in the TBR4100. This optically isolated four-channel free radical analyzer has ultra low noise and independently operated channels.
The TBRis designed for use with WPI’s wide range of nitric oxide, hydrogen peroxide, hydrogen sulfide and oxygen sensors. The TBR4100 can measure four different species simultaneously in the same preparation. Simply plug a sensor into the input channel on the front panel and select the current range. Poise voltage can be selected from a range of values tuned for optimal response from WPI sensors. An independent output for real-time monitoring of temperature is also included.
The TBR1025 analyzer utilizes PC-based data acquisition via our Lab-Trax interface. Data traces are displayed and recorded in real-time. The LabScribe software (formerly called DataTrax) comes pre-configured for single or multiple electrode recording; filters, gains, and smoothing are all set for optimal results. Data can be viewed making adjustments to smoothing and filter settings without affecting the original stored raw data. Electrode calibration from multiple concentration readings can be input into the software"s Multipoint Calibration utility quickly provides a plot and slope calculation for electrode sensitivity determination.
Alternately, the Lab-Trax data interface can be used for providing simultaneous acquisition of Free Radical data along with other physiological data (ECG, HR, BP, etc.) as each of the four input channels has its own independent input, filters and 24-bit converter.
TBR4100-416 includes TBR4100 analyzer and power cord, Lab-Trax-4/16 data loggersystem and USB cable, 4 BNC cables, 3 electrode adapter cables, 1 temperature probe, 2 sensors of your choice, and sensor start-up kit(s), if applicable.
Manuals
TBR Instruction ManualLabScribe 3 Instruction Manual
Sample Files – ZIP file including hardware and software manuals, NO Demo recording, concentration spreadsheet examples. (Templates_LS3.zip)
Power | 100 ~ 240 VAC, 50-60 Hz, | ||||||||||||||||||||
Operating Temperature (ambient) | 0 - 50°C (32 - 122°F) | ||||||||||||||||||||
Operating Humidity (ambient) | 15 - 70% RH non-condensing | ||||||||||||||||||||
Warm up Time | < 5 min. | ||||||||||||||||||||
Dimensions | 135 X 419 X 217 mm (5.25" X 16.5" X 8.16") | ||||||||||||||||||||
Weight | 1.35 kg (3 lb.) | ||||||||||||||||||||
Display Functions | 18 mm (0.7") LCD readout, 4.5 digit Polarization Voltage (mV) Current input (nA, µA) | ||||||||||||||||||||
Controls | Power (on/off) Current Input Range Polarization Voltage | ||||||||||||||||||||
Analog Output Range | ±10 V (continuous) | ||||||||||||||||||||
Analog Output Impedance | 10 KΩ | ||||||||||||||||||||
Channel to Channel Isolation | >10 GΩ | ||||||||||||||||||||
Channel to Output Isolation | >10 GΩ | ||||||||||||||||||||
Power Supply to AC Line Isolation | >100 MΩ | ||||||||||||||||||||
Analog Output Drift | < 10 pA/hr. | ||||||||||||||||||||
Temperature Input: Number of Channels | 1 | ||||||||||||||||||||
Temperature Input: Sensing Element | Platinum RTD, 1000 Ω | ||||||||||||||||||||
Temperature Input: Range | 0-100°C | ||||||||||||||||||||
Temperature Input: Accuracy | ± 1°C | ||||||||||||||||||||
Temperature Input: Resolution | 0.1°C | ||||||||||||||||||||
Temperature Input: Analog Output | 31.25 mV/°C (continuous) | ||||||||||||||||||||
Amperometric Input: Number of Amperometric Channels | 4 | ||||||||||||||||||||
Amperometric Input: Signal Bandwidth | 0-3 Hz | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) Nitric Oxide | 865 mV | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) Hydrogen Sulfide | 150 mV | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) Hydrogen Peroxide | 450 mV | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) Glucose | 600 mV | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) Oxygen | 700 mV | ||||||||||||||||||||
Amperometric Input: Polarization Voltage (selectable via rotary switch) ADJ (user adjustable) | ± 2500 mV | ||||||||||||||||||||
Polarization Voltage Accuracy | ± 5 mV | ||||||||||||||||||||
Polarization Voltage Display Resolution | ± 1mV | ||||||||||||||||||||
Current measurement Performance: |
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Notes: | *Instrument performance is measured as the (max-min) over 20 seconds period with open input. Typical values are given at 3 Hz and 0.3 Hz bandwidth. | ||||||||||||||||||||
Typical sensor performance with TBR4100: ISO-NOPF100 noise | 0.2 nM NO (< 2pA **) | ||||||||||||||||||||
Notes: | **Sensor noise is measured as the (max-min) over a 20 seconds period with the sensor immersed in 0.1 M CuCl2 solution. |
Silveira, N. M., Seabra, A. B., Marcos, F. C. C., Pelegrino, M. T., Machado, E. C., & Ribeiro, R. V. (2019). Encapsulation of S-nitrosoglutathione into chitosan nanoparticles improves drought tolerance of sugarcane plants. Nitric Oxide, 84, 38–44. https://doi.org/10.1016/J.NIOX.2019.01.004
Wang, J., Wang, W., Li, S., Han, Y., Zhang, P., Meng, G., … Ji, Y. (2018). Hydrogen Sulfide As a Potential Target in Preventing Spermatogenic Failure and Testicular Dysfunction. Antioxidants & Redox Signaling, 28(16), 1447–1462. https://doi.org/10.1089/ars.2016.6968
Meng, G., Liu, J., Liu, S., Song, Q., Liu, L., Xie, L., … Ji, Y. (2018). Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner. British Journal of Pharmacology, 175(8), 1126–1145. https://doi.org/10.1111/bph.13861
Gonçalves, L. C., Seabra, A. B., Pelegrino, M. T., de Araujo, D. R., Bernardes, J. S., & Haddad, P. S. (2017). Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications. RSC Advances, 7(24), 14496–14503. https://doi.org/10.1039/C6RA28633J
Calvo-Begueria, L., Cuypers, B., Van Doorslaer, S., Abbruzzetti, S., Bruno, S., Berghmans, H., … Becana, M. (2017). Characterization of the Heme Pocket Structure and Ligand Binding Kinetics of Non-symbiotic Hemoglobins from the Model Legume Lotus japonicus. Frontiers in Plant Science, 8, 407. https://doi.org/10.3389/fpls.2017.00407
Fang, H., Liu, Z., Long, Y., Liang, Y., Jin, Z., Zhang, L., … Pei, Y. (2017). The Ca 2+ /calmodulin2-binding transcription factor TGA3 elevates LCD expression and H 2 S production to bolster Cr 6+ tolerance in Arabidopsis. The Plant Journal, 91(6), 1038–1050. https://doi.org/10.1111/tpj.13627
Steiger, A. K., Marcatti, M., Szabo, C., Szczesny, B., & Pluth, M. D. (2017). Inhibition of Mitochondrial Bioenergetics by Esterase-Triggered COS/H 2 S Donors. ACS Chemical Biology, 12(8), 2117–2123. https://doi.org/10.1021/acschembio.7b00279
Murine strain differences in inflammatory angiogenesis of internal wound in diabetes. (2017). Biomedicine & Pharmacotherapy, 86, 715–724. https://doi.org/10.1016/J.BIOPHA.2016.11.146
Pokrzywinski, K. L., Tilney, C. L., Warner, M. E., & Coyne, K. J. (2017). Cell cycle arrest and biochemical changes accompanying cell death in harmful dinoflagellates following exposure to bacterial algicide IRI-160AA. Scientific Reports, 7(1), 45102. https://doi.org/10.1038/srep45102
da Silva, C. J., Batista Fontes, E. P., & Modolo, L. V. (2017). Salinity-induced accumulation of endogenous H2S and NO is associated with modulation of the antioxidant and redox defense systems in Nicotiana tabacum L. cv. Havana. Plant Science, 256, 148–159. https://doi.org/10.1016/j.plantsci.2016.12.011
Olson, K. R., Gao, Y., DeLeon, E. R., Arif, M., Arif, F., Arora, N., & Straub, K. D. (2017). Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS). Redox Biology, 12, 325–339. https://doi.org/10.1016/j.redox.2017.02.021
Wan, F., Shi, M., & Gao, H. (2017). Loss of OxyR reduces efficacy of oxygen respiration in Shewanella oneidensis. Scientific Reports, 7(1), 42609. https://doi.org/10.1038/srep42609
Maiocchi, S. L., Morris, J. C., Rees, M. D., & Thomas, S. R. (2017). Regulation of the nitric oxide oxidase activity of myeloperoxidase by pharmacological agents. Biochemical Pharmacology, 135, 90–115. https://doi.org/10.1016/j.bcp.2017.03.016
Santos, S. S., Jesus, R. L. C., Simões, L. O., Vasconcelos, W. P., Medeiros, I. A., Veras, R. C., … Silva, D. F. (2017). NO production and potassium channels activation induced by Crotalus durissus cascavella underlie mesenteric artery relaxation. Toxicon, 133, 10–17. https://doi.org/10.1016/j.toxicon.2017.04.010
Bertozo, L. de C., Zeraik, M. L., & Ximenes, V. F. (2017). Dansylglycine, a fluorescent probe for specific determination of halogenating activity of myeloperoxidase and eosinophil peroxidase. Analytical Biochemistry, 532, 29–37. https://doi.org/10.1016/j.ab.2017.05.029
Mogen, A. B., Carroll, R. K., James, K. L., Lima, G., Silva, D., Culver, J. A., … Rice, K. C. (2017). S taphylococcus aureus nitric oxide synthase (saNOS) modulates aerobic respiratory metabolism and cell physiology. Molecular Microbiology, 105(1), 139–157. https://doi.org/10.1111/mmi.13693
Huang, P., Shen, Z., Yu, W., Huang, Y., Tang, C., Du, J., & Jin, H. (2017). Hydrogen Sulfide Inhibits High-Salt Diet-Induced Myocardial Oxidative Stress and Myocardial Hypertrophy in Dahl Rats. Frontiers in Pharmacology, 08, 128. https://doi.org/10.3389/fphar.2017.00128
Zadehvakili, B., McNeill, S. M., Fawcett, J. P., & Giles, G. I. (2016). The design of redox active thiol peroxidase mimics: Dihydrolipoic acid recognition correlates with cytotoxicity and prooxidant action. Biochemical Pharmacology, 104, 19–28. https://doi.org/10.1016/j.bcp.2016.01.012
Xu, T., Scafa, N., Xu, L.-P., Zhou, S., Abdullah Al-Ghanem, K., Mahboob, S., … Zhang, X. (2016). Electrochemical hydrogen sulfide biosensors. The Analyst, 141(4), 1185–1195. https://doi.org/10.1039/C5AN02208H
Oliveira, H. C., Gomes, B. C. R., Pelegrino, M. T., & Seabra, A. B. (2016). Nitric oxide-releasing chitosan nanoparticles alleviate the effects of salt stress in maize plants. Nitric Oxide, 61, 10–19. https://doi.org/10.1016/j.niox.2016.09.010
Xie, L., Feng, H., Li, S., Meng, G., Liu, S., Tang, X., … Ji, Y. (2016). SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxidants & Redox Signaling, 24(6), 329–343. https://doi.org/10.1089/ars.2015.6331
Song, R., Liu, G., Li, X., Xu, W., Liu, J., & Jin, H. (2016). Elevated Inducible Nitric Oxide Levels and Decreased Hydrogen Sulfide Levels Can Predict the Risk of Coronary Artery Ectasia in Kawasaki Disease. Pediatric Cardiology, 37(2), 322–329. https://doi.org/10.1007/s00246-015-1280-8
Silveira, N. M., Frungillo, L., Marcos, F. C. C., Pelegrino, M. T., Miranda, M. T., Seabra, A. B., … Ribeiro, R. V. (2016). Exogenous nitric oxide improves sugarcane growth and photosynthesis under water deficit. Planta, 244(1), 181–190. https://doi.org/10.1007/s00425-016-2501-y
DeLeon, E. R., Gao, Y., Huang, E., Arif, M., Arora, N., Divietro, A., … Olson, K. R. (2016). A case of mistaken identity: are reactive oxygen species actually reactive sulfide species? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 310(7), R549–R560. https://doi.org/10.1152/ajpregu.00455.2015
Meng, G., Xiao, Y., Ma, Y., Tang, X., Xie, L., Liu, J., … Ji, Y. (2016). Hydrogen Sulfide Regulates Krüppel-Like Factor 5 Transcription Activity via Specificity Protein 1 S-Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy. Journal of the American Heart Association, 5(9). https://doi.org/10.1161/JAHA.116.004160
Ultrasonic micro-droplet release of matrix bound food derived antimicrobials. (2016).
Deng, Q., Xiang, H.-J., Tang, W.-W., An, L., Yang, S.-P., Zhang, Q.-L., & Liu, J.-G. (2016). Ruthenium nitrosyl grafted carbon dots as a fluorescence-trackable nanoplatform for visible light-controlled nitric oxide release and targeted intracellular delivery. Journal of Inorganic Biochemistry, 165, 152–158. https://doi.org/10.1016/J.JINORGBIO.2016.06.011
Wonoputri, V., Gunawan, C., Liu, S., Barraud, N., Yee, L. H., Lim, M., & Amal, R. (2016). Iron Complex Facilitated Copper Redox Cycling for Nitric Oxide Generation as Nontoxic Nitrifying Biofilm Inhibitor. ACS Applied Materials & Interfaces, 8(44), 30502–30510. https://doi.org/10.1021/acsami.6b10357
Nguyen, T.-K., Selvanayagam, R., Ho, K. K. K., Chen, R., Kutty, S. K., Rice, S. A., … Boyer, C. (2016). Co-delivery of nitric oxide and antibiotic using polymeric nanoparticles. Chem. Sci., 7(2), 1016–1027. https://doi.org/10.1039/C5SC02769A
Chen, G., Yang, L., Zhong, L., Kutty, S., Wang, Y., Cui, K., … Bin, J. (2016). Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury. Scientific Reports, 6(1), 30643. https://doi.org/10.1038/srep30643
Zhang, W., Zhang, Y. S., Bakht, S. M., Aleman, J., Shin, S. R., Yue, K., … Khademhosseini, A. (2016). Elastomeric free-form blood vessels for interconnecting organs on chip systems. Lab on a Chip, 16(9), 1579–1586. https://doi.org/10.1039/C6LC00001K
Huang, P., Chen, S., Wang, Y., Liu, J., Yao, Q., Huang, Y., … Jin, H. (2015). Down-regulated CBS/H2S pathway is involved in high-salt-induced hypertension in Dahl rats. Nitric Oxide, 46, 192–203. https://doi.org/10.1016/j.niox.2015.01.004
Zong, Y., Huang, Y., Chen, S., Zhu, M., Chen, Q., Feng, S., … Jin, H. (2015). Downregulation of Endogenous Hydrogen Sulfide Pathway Is Involved in Mitochondrion-Related Endothelial Cell Apoptosis Induced by High Salt. Oxidative Medicine and Cellular Longevity, 2015, 1–11. https://doi.org/10.1155/2015/754670
Park, Y. M., Lee, H. J., Jeong, J.-H., Kook, J.-K., Choy, H. E., Hahn, T.-W., & Bang, I. S. (2015). Branched-chain amino acid supplementation promotes aerobic growth of Salmonella Typhimurium under nitrosative stress conditions. Archives of Microbiology, 197(10), 1117–1127. https://doi.org/10.1007/s00203-015-1151-y
Wonoputri, V., Gunawan, C., Liu, S., Barraud, N., Yee, L. H., Lim, M., & Amal, R. (2015). Copper Complex in Poly(vinyl chloride) as a Nitric Oxide-Generating Catalyst for the Control of Nitrifying Bacterial Biofilms. ACS Applied Materials & Interfaces, 7(40), 22148–22156. https://doi.org/10.1021/acsami.5b07971
Ostrakhovitch, E. A., Akakura, S., Sanokawa-Akakura, R., Goodwin, S., & Tabibzadeh, S. (2015). Dedifferentiation of cancer cells following recovery from a potentially lethal damage is mediated by H2S–Nampt. Experimental Cell Research, 330(1), 135–150. https://doi.org/10.1016/j.yexcr.2014.09.027
Sun, Y., Huang, Y., Zhang, R., Chen, Q., Chen, J., Zong, Y., … Jin, H. (2015). Hydrogen sulfide upregulates KATP channel expression in vascular smooth muscle cells of spontaneously hypertensive rats. Journal of Molecular Medicine, 93(4), 439–455. https://doi.org/10.1007/s00109-014-1227-1
Cho, Y., Park, Y. M., Barate, A. K., Park, S.-Y., Park, H. J., Lee, M. R., … Holden, D. (2015). The role of rpoS , hmp , and ssrAB in Salmonella enterica Gallinarum and evaluation of a triple-deletion mutant as a live vaccine candidate in Lohmann layer chickens. Journal of Veterinary Science, 16(2), 187. https://doi.org/10.4142/jvs.2015.16.2.187
Bełtowski, J., Guranowski, A., Jamroz-Wiśniewska, A., Wolski, A., & Hałas, K. (2015). Hydrogen-sulfide-mediated vasodilatory effect of nucleoside 5′-monophosphorothioates in perivascular adipose tissue. Canadian Journal of Physiology and Pharmacology, 93(7), 585–595. https://doi.org/10.1139/cjpp-2014-0543
Mocca, B., Yin, D., Gao, Y., & Wang, W. (2015). Moraxella catarrhalis -produced nitric oxide has dual roles in pathogenicity and clearance of infection in bacterial-host cell co-cultures. Nitric Oxide, 51, 52–62. https://doi.org/10.1016/j.niox.2015.10.001
Orellano, L. A. A., Almeida, S. A., Campos, P. P., & Andrade, S. P. (2015). Angiopreventive versus angiopromoting effects of allopurinol in the murine sponge model. Microvascular Research, 101, 118–126. https://doi.org/10.1016/j.mvr.2015.07.003
Tan, L., Wan, A., Zhu, X., & Li, H. (2014). Visible light-triggered nitric oxide release from near-infrared fluorescent nanospheric vehicles. The Analyst, 139(13), 3398. https://doi.org/10.1039/c4an00275j
Liu, S., Gu, T., Fu, J., Li, X., Chronakis, I. S., & Ge, M. (2014). Quantum dots-hyperbranched polyether hybrid nanospheres towards delivery and real-time detection of nitric oxide. Materials Science and Engineering: C, 45, 37–44. https://doi.org/10.1016/j.msec.2014.08.070
Sanokawa-Akakura, R., Ostrakhovitch, E. A., Akakura, S., Goodwin, S., & Tabibzadeh, S. (2014). A H 2 S-Nampt Dependent Energetic Circuit Is Critical to Survival and Cytoprotection from Damage in Cancer Cells. https://doi.org/10.1371/journal.pone.0108537
Dantas, B. P. V, Ribeiro, T. P., Assis, V. L., Furtado, F. F., Assis, K. S., Alves, J. S., … Braga, V. A. (2014). Vasorelaxation induced by a new naphthoquinone-oxime is mediated by NO-sGC-cGMP pathway. Molecules (Basel, Switzerland), 19(7), 9773–9785. https://doi.org/10.3390/molecules19079773
Dunlop, K., Gosal, K., Kantores, C., Ivanovska, J., Dhaliwal, R., Desjardins, J.-F., … Jankov, R. P. (2014). Therapeutic hypercapnia prevents inhaled nitric oxide-induced right-ventricular systolic dysfunction in juvenile rats. Free Radical Biology and Medicine, 69, 35–49. https://doi.org/10.1016/j.freeradbiomed.2014.01.008
Yarmolinsky, D., Brychkova, G., Kurmanbayeva, A., Bekturova, A., Ventura, Y., Khozin-Goldberg, I., … Sagi, M. (2014). Impairment in Sulfite Reductase Leads to Early Leaf Senescence in Tomato Plants. Plant Physiology, 165(4), 1505–1520. https://doi.org/10.1104/pp.114.241356
Diniz, T., Pereira, A., Capettini, L., Santos, M., Nagem, T., Lemos, V., & Cortes, S. (2013). Mechanism of the Vasodilator Effect of Mono-oxygenated Xanthones: A Structure-Activity Relationship Study. Planta Medica, 79(16), 1495–1500. https://doi.org/10.1055/s-0033-1350803
Process of food preservation with hydrogen sulfide. (2013).
Dick, A. S., Ivanovska, J., Kantores, C., Belcastro, R., Keith Tanswell, A., & Jankov, R. P. (2013). Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Free Radical Biology and Medicine, 61, 310–319. https://doi.org/10.1016/j.freeradbiomed.2013.04.027
Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds. (2013).
Olson, K. R., DeLeon, E. R., Gao, Y., Hurley, K., Sadauskas, V., Batz, C., & Stoy, G. F. (2013). Thiosulfate: a readily accessible source of hydrogen sulfide in oxygen sensing. Am J Physiol Regul Integr Comp Physiol, 305, 592–603. https://doi.org/10.1152/ajpregu.00421.2012
Araújo, F. A., Rocha, M. A., Capettini, L. S. A., Campos, P. P., Ferreira, M. A. N. D., Lemos, V. S., & Andrade, S. P. (2013). 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (fluvastatin) decreases inflammatory angiogenesis in mice. APMIS, 121(5), 422–430. https://doi.org/10.1111/apm.12031
Aljuhani, N., Michail, K., Karapetyan, Z., & Siraki, A. G. (2013). The effect of bicarbonate on menadione-induced redox cycling and cytotoxicity: potential involvement of the carbonate radical. Canadian Journal of Physiology and Pharmacology, 91(10), 783–790. https://doi.org/10.1139/cjpp-2012-0254
Tan, L., Wan, A., & Li, H. (2013). Ag 2 S Quantum Dots Conjugated Chitosan Nanospheres toward Light-Triggered Nitric Oxide Release and Near-Infrared Fluorescence Imaging. Langmuir, 29(48), 15032–15042. https://doi.org/10.1021/la403028j
Catalytic oxidation of sulphide species. (2012).
Andrews, A. M. (2012). SHEAR STRESS-INDUCED NITRIC OXIDE (NO) PRODUCTION: MECHANISMS AND THE INHIBITORY EFFECT OF CHOLESTEROL ENRICHMENT.
An, J., Du, J., Wei, N., Guan, T., Camara, A. K. S., & Shi, Y. (2012). Differential Sensitivity to LPS-Induced Myocardial Dysfunction in the Isolated Brown Norway and DAHL S Rat Hearts. Shock, 37(3), 325–332. https://doi.org/10.1097/SHK.0b013e31823f146f
Liu, J. T., Song, E., Xu, A., Berger, T., Mak, T. W., Tse, H.-F., … Wang, Y. (2012). Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition. British Journal of Pharmacology, 165(2), 520–531. https://doi.org/10.1111/j.1476-5381.2011.01587.x
Fox, B., Schantz, J.-T., Haigh, R., Wood, M. E., Moore, P. K., Viner, N., … Whiteman, M. (2012). Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint? Journal of Cellular and Molecular Medicine, 16(4), 896–910. https://doi.org/10.1111/j.1582-4934.2011.01357.x
Liu, J. T., Song, E., Xu, A., Berger, T., Mak, T. W., Tse, H.-F., … Wang, Y. (2012). Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition. British Journal of Pharmacology, 165(2), 520–531. https://doi.org/10.1111/j.1476-5381.2011.01587.x
Marazioti, A., Bucci, M., Coletta, C., Vellecco, V., Baskaran, P., Szabó, C., … Papapetropoulos, A. (2011). Inhibition of Nitric Oxide–Stimulated Vasorelaxation by Carbon Monoxide-Releasing Molecules. Arteriosclerosis, Thrombosis, and Vascular Biology, 31(11), 2570–2576. https://doi.org/10.1161/ATVBAHA.111.229039
Young, L. H., Chen, Q., & Weis, M. T. (2011). Direct Measurement of Hydrogen Peroxide (H 2 O 2 ) or Nitric Oxide (NO) Release: A Powerful Tool to Assess Real-time Free Radical Production in Biological Models. Am. J. Biomed. Sci, 3(1), 40–48. https://doi.org/10.5099/aj110100040
Araújo, F. A., Rocha, M. A., Ferreira, M. A., Campos, P. P., Capettini, L. S., Lemos, V. S., & Andrade, S. P. (2011). Implant-induced intraperitoneal inflammatory angiogenesis is attenuated by fluvastatin. Clinical and Experimental Pharmacology and Physiology, 38(4), 262–268. https://doi.org/10.1111/j.1440-1681.2011.05496.x
Leistikow, R. L., Morton, R. A., Bartek, I. L., Frimpong, I., Wagner, K., & Voskuil, M. I. (2010). The Mycobacterium tuberculosis DosR Regulon Assists in Metabolic Homeostasis and Enables Rapid Recovery from Nonrespiring Dormancy. Journal of Bacteriology, 192(6), 1662–1670. https://doi.org/10.1128/JB.00926-09
Honaker, R. W., Dhiman, R. K., Narayanasamy, P., Crick, D. C., & Voskuil, M. I. (2010). DosS Responds to a Reduced Electron Transport System To Induce the Mycobacterium tuberculosis DosR Regulon. Journal of Bacteriology, 192(24), 6447–6455. https://doi.org/10.1128/JB.00978-10
Andrews, A. M., Jaron, D., Buerk, D. G., Kirby, P. L., & Barbee, K. A. (2010). Direct, real-time measurement of shear stress-induced nitric oxide produced from endothelial cells in vitro. Nitric Oxide, 23(4), 335–342. https://doi.org/10.1016/j.niox.2010.08.003
Pandolfi, C., Pottosin, I., Cuin, T., Mancuso, S., & Shabala, S. (2010). Specificity of Polyamine Effects on NaCl-induced Ion Flux Kinetics and Salt Stress Amelioration in Plants. Plant and Cell Physiology, 51(3), 422–434. https://doi.org/10.1093/pcp/pcq007
Whiteman, M., Li, L., Rose, P., Tan, C.-H., Parkinson, D. B., & Moore, P. K. (2010). The Effect of Hydrogen Sulfide Donors on Lipopolysaccharide-Induced Formation of Inflammatory Mediators in Macrophages. Antioxidants & Redox Signaling, 12(10), 1147–1154. https://doi.org/10.1089/ars.2009.2899
Lateef, H., Aslam, M. N., Stevens, M. J., & Varani, J. (2005). Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds. Archives of Dermatological Research, 297(2), 75–83. https://doi.org/10.1007/s00403-005-0576-6
"The Effects of Modulating Endothelial Nitric Oxide Synthese (eNOS) Activity and Coupling in Extracorporeal Shock Wave Lithotripsy (ESWL)" by Alexandra Lopez. (n.d.). Retrieved November 12, 2018, from https://works.bepress.com/qian_chen/25/
The video below shows how to calibrate your oxygen sensor (6 minutes).
WPI(World Precision Instruments Inc.)公司的使命是给神经生理学、心血管生理学和细胞生物学等广大 生物医学科研工作者提供研究用的仪器和工具,使其研究更完善,更**,更精确。WPI China将秉承WPI的理念为中国大陆,中国香港和台湾地区科学 研究者提供优质的产品和周到的服务。
近年来,WPI产品线由神经电生理产品逐渐延伸到生物感应器,心血管生理、病理和心血管药理,光谱检测等领域,革新的产品包括:
WPI-TBR1025/4100, 一氧化氮、硫化氢和过氧化氢等自由基检测仪为全球**和行业领导供应商。
EVOM2, 一款可以在6孔、12孔、24孔和96孔培养板中进行跨膜电阻测量的跨膜电阻仪,是该领域的产品风向标,用于上皮、内皮和肿瘤细胞培养过程中细胞状态的检测,并常用于药物动力学研究和肿瘤药效检测。
WPI-LWCC, 世界上**可以将光程做到2米以上微量样本检测流通池的生产厂家,可以用于海洋微量元素和环境微量物质的检测。
微量注射系统:PV系列气动微量注射系统用于质粒转染和细胞内注射;纳升微量注射系统可以确保您注射的精确到纳升级;多款微注射系统任您选择。
WPI的历史超过40年,在美国、英国、德国、加拿大、澳大利亚、新西兰、法国等欧美生物医学实验室是****的领导供应商之一,供应实验室产品种类超过5000种。我们也将为国内的科学家提供包含神经电生理、生物感应器、心血管和光谱等成套设备的销售及服务,同时提供数据采集系统 、动物实验等手术器械和玻璃毛细管等耗材的销售及服务。